AlphaGenome
AlphaGenome
- AlphaGenome** is a large-scale deep-learning system developed by DeepMind to predict how segments of DNA regulate gene expression and how single-nucleotide variants may disrupt that regulation. It was launched on 25 June 2025. Subject to following the terms of use, the API can be used free of charge, for non-commercial use.
Background Ever since the first draft of the human genome appeared in 2001, most of its over 3 billion letters have remained functionally opaque.
The model can predict across 11 modalities concurrently: RNA-seq, CAGE and PRO-cap (gene expression), splice sites, splice site usage and splice junctions (splicing patterns), DNase, ATAC-seq, histone modifications and transcription factor binding (chromatin state) and chromatin contact maps. An evaluation of 24 genome tracks, using all 11 modalities found that AlphaGenome outperformed the best alternative models in 22 of these evaluations. Current limitations include difficulty in predicting the effects of mutations on genes located more than 100,000 base pairs away.